Bioactive Small Molecules
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Filtered Search Results
Cayman Chemical ANTIBODY PRN-1371 10mg
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An irreversible pan-FGFR inhibitor (IC50s = 0.7, 1.3, 4.4, and 19.3 nM for FGFR-1, -2, -3, and -4, respectively); selective for FGFR over VEGFR2 (IC50 = 705 nM) and a panel of 250 kinases (IC50s = >1 µM for all) but does inhibit CSF1R activity by >90% at 1 µM; inhibits proliferation in a panel of ten cancer cell lines containing various FGFR mutants (IC50s = 2-231 nM) and induces apoptosis in SNU-16 gastric and RT4 bladder cancer cells (EC50s = 15.9 and 11.8 nM, respectively); reduces tumor growth in an SNU-16 mouse xenograft model and a PDX mouse model of liver cancer at 15 mg/kg twice per day
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Selleck Chemical LLC Bafetinib S1369-25mg
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Bafetinib is a potent and selective dual Bcr-Abl/Lyn inhibitor with IC50 of 5 8 nM/19 nM in cell-free assays does not inhibit the phosphorylation of the T315I mutant and is less potent to PDGFR and c-Kit
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Selleck Chemical LLC BIX 02188 S1530-5mg
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BIX02188 is a selective inhibitor of MEK5 with IC50 of 4 3 nM also inhibits ERK5 catalytic activity with IC50 of 810 nM and does not inhibit closely related kinases MEK1 MEK2 ERK2 and JNK2
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Selleck Chemical LLC BAY-293 S8826-100MG
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BAY-293 selectively inhibits the KRAS-SOS1 interaction with an IC50 of 21 nM
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Selleck Chemical LLC Lanraplenib S9715-5MG
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Lanraplenib (GS-SYK)is a potent highly selective and orally active inhibitor of Spleen Tyrosine Kinase (SYK) with IC50 of 9 5 nM Lanraplenib inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans
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Selleck Chemical LLC STM2457 S9870-100MG
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STM2457 is a highly potent and selective first-in-class catalytic inhibitor of RNA Methyltransferase METTL3 with an IC50 of 16 9 nM STM2457 is highly specific for METTL3 and showed no inhibition of other RNA methyltransferases
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Selleck Chemical LLC Futibatinib S8848-10MM/1ML
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Futibatinib (TAS-120) is an irreversible fibroblast growth factor receptor (FGFR) inhibitor which inhibits all 4 subtypes of FGFR with enzyme IC50 values of 1 8 nM 1 4 nM 1 6 nM and 3 7 nM for FGFR1 FGFR2 FGFR3 and FGFR4 respectively
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Selleck Chemical LLC 4-HNE S9793-1G
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4-HNE (4-Hydroxynonenal) is one of the major end products of lipid peroxidation and has been widely accepted as an inducer of oxidative stress
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Selleck Chemical LLC APG-2575 S9970-25MG
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APG-2575 (lisaftoclax) is a dual Bcl-2 and Bcl-xl inhibitor with IC50 values of 2 nM and 5 9 nM for Bcl-2 and Bcl-xl respectively
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Selleck Chemical LLC Sequoyitol S9343-1MG
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Sequoia alcohol (Sequoyitol) is isolated from Taxus natural organic compounds it can be used to treat diabetes and other indications
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Selleck Chemical LLC 78-Dihydroxy-4-phenylcoumarin S9356-1G
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7 8-Dihydroxy-4-phenylcoumarin is an intermediate
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Selleck Chemical LLC Aristolone S9283-1MG
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Aristolone which could be extracted from essential oil of Elyonurus hensii is likely to induce an antalgic activity
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Selleck Chemical LLC Atuveciclib S8727-10MM/1ML
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Atuveciclib (BAY-1143572) is a potent and highly selective PTEFb/CDK9 inhibitor with IC50 values of 13 nM for CDK9/CycT and the ratio of IC50 values for CDK2/CDK9 is about 100 Outside the CDK family It inhibits GSK3 kinase with IC50 values of 45 nM and 87 nM for GSK3 and GSK3 respectively
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Selleck Chemical LLC Spinosin S9134-1MG
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Spinosin (Flavoayamenin) a avone-C-glycoside is a bioactive ingredient isolated from a traditional Chinese herb Zizyphi Spinosi Semen It acts as a plant metabolite and an anxiolytic drug
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Medchemexpress LLC P18IN003 | 71727-40-7 | 99.5% | 296.32 g/mol | C17H16N2O3 | 5MG
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P18IN003 is a small-molecule inhibitor that selectively targets p18 (INK4C), a cyclin-dependent kinase regulator. It is intended for research use in studies of cell cycle regulation and hematopoietic stem cell expansion, and is characterized with defined physicochemical properties and storage recommendations.
- Selective inhibitor of p18 (INK4C) for research and cell cycle studies.
- Demonstrated potential to promote hematopoietic stem cell expansion.
- CAS 71727-40-7 for unambiguous substance identification.
- Chemical formula C17H16N2O3, molecular weight 296.32 g/mol.
- High purity (99.5%) and white to off-white solid appearance.
- Recommended storage: 4°C protected from light; in solvent store at -80°C (6 months) or -20°C (1 month).
- Available in multiple pack sizes including 5 MG, 10 MG, 25 MG, 50 MG, and 100 MG.
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