Bioactive Small Molecules

A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.

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5,296 – 5,310 of 60,541 results

5,296

Cayman Chemical Dienogest, Purity: ≥98%, CAS: 65928-58-7, 50 mg

A synthetic progestin and PR agonist (EC50s = 3.4-10.5 nM in transactivation assays); selective for PR over ERα and ERβ, as well as glucocorticoid, and mineralocorticoid receptors (EC50s = >3,000 nM for all), as well as SHBG and CBG (IC50s = 900-950 and 7,970 nM, respectively, in radioligand binding assays); inhibits dihydrotestosterone-induced transactivation of the androgen receptor (EC50s = 420.6-775 nM); reduces lesion formation in a rat model of endometriosis at 0.1, 0.3, and 1 mg/kg per day for 21 days orally; reduces 17β-estradiol benzoate-dependent tumor growth in an MCF-7 ovariectomized mouse xenograft model at 0.1 and 1 mg/kg per day for 28 days

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5,297

Medchemexpress LLC Umibecestat | 1387560-01-1 | 99.8% | 5 MG

Umibecestat is a potent, selective BACE-1 (beta-secretase) inhibitor used for research into Alzheimer's disease. It exhibits low-nanomolar inhibition of human and mouse BACE-1 and is supplied in small research pack sizes suitable for in vitro studies.

Potent BACE-1 inhibitor with IC50 ≈ 11 nM (human) and 10 nM (mouse).
Suitable for Alzheimer's disease research and in vitro assays.
High solubility in DMSO (~100 mg/mL) with ultrasonic assistance.
Store solid at 4°C; in solution store at -80°C (6 months) or -20°C (1 month), protected from light.

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5,298

Carbosynth LLC. 6-EPIDOXYCYCLINE HYDROCHL 10MG

6-Epidoxycycline hydrochloride 10mg; CAS No: 41411-66-9; Molecular Weight: 480.9 g/mol; MFCD25977176; BIOSYNTH/Carbosynth

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5,299

Selleck Chemical LLC IFN alpha-IFNAR-IN-1 HCl E2982-5MG

IFN alpha-IFNAR-IN-1 hydrochloride is a nonpeptidic low-molecular-weight inhibitor that inhibits the interaction between IFN- and IFNAR IFN alpha-IFNAR-IN-1 hydrochloride inhibits modified Vaccinia virus ankara (MVA)-induced IFN- responses in murine bone-marrow-derived Flt3- L-differentiated pDC cultures (BM-pDCs) with IC50 value of 2-8 M

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5,300

Cayman Chemical AZ 32, Purity: ≥98%, CAS: 2288709-96-4, 10 mg

An ATM kinase inhibitor (IC50 = 50s = 4.6 and >4.6 µM, respectively); enhances radiation-induced cytotoxicity in a panel of five human glioma cells expressing wild-type or mutant p53; increases survival in a U87-281G glioma orthotopic mouse xenograft model, as well as a NCI H2228 NSCLC mouse xenograft model of metastatic brain tumors, at 200 and 50 mg/kg, respectively, in combination with ionizing radiation

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5,301

Cayman Chemical Moxonidine, Purity: ≥95%, CAS: 75438-57-2, 25 mg

An imidazoline I1 and α2A-AR agonist (Kis = 56 and 150 nM, respectively, in radioligand binding assays); selective for α2A-AR and I1 receptors over α1-, α2B, and α2C-ARs (Kis = >30,000, 1,000, and 2,000 nM, respectively); decreases mean arterial pressure in spontaneously hypertensive rats at 0.2 nmol injected into the RVLM; reduces blood pressure in cynomolgus monkeys at 167 µg/kg

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5,302

Cayman Chemical Metyrosine, Purity: ≥98%, CAS: 672-87-7, 50 mg

An inhibitor of tyrosine hydroxylase; reduces norepinephrine and dopamine levels in rat brains when administered at a dose of 200 mg/kg; disrupts conditioned avoidance behavior in a dose-dependent manner; reduces dexamethasone- and cyclosporin-induced hypertension in rats

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5,303

Cayman Chemical Dooku1, Purity: ≥98%, CAS: 2253744-54-4, 10 mg

An antagonist of yoda1-activated Piezo1 (IC50 = 1.3 µM in HEK293 cells expressing the human receptor); selective for yoda1-actived Piezo1 over constituitively active Piezo1, TRPV4, and TRPC4 at 10 µM; reduces the percentage of cells with yoda1-induced extracellular phosphatidylserine exposure in RBCs isolated from patients with sickle cell anemia at 10 µM; inhibits yoda1-induced relaxation of isolated mouse aortic rings at 10 µM

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5,304

Medchemexpress LLC Laropiprant | 571170-77-9 | 99.3% | 435.90 | 100 MG

Laropiprant is a potent and selective DP receptor antagonist, exhibiting Ki values of 0.57 nM for the DP receptor and 2.95 nM for the TP Receptor. In vitro studies show Laropiprant acts as an inverse agonist of DP1 cAMP signaling, reducing basal DP1 cAMP levels.

Potent and selective DP receptor antagonist
Exhibits Ki values of 0.57 nM for DP receptor and 2.95 nM for TP receptor
Acts as an inverse agonist of DP1 cAMP signaling in HEK293 cells
Promotes DP1 cell surface expression as a pharmacochaperone
Shows good pharmacokinetic profiles in in vivo studies

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5,305

Cayman Chemical JWH 122 N-(5-hydroxypentyl) metabolite, Purity: ≥98%, CAS: 1379604-68-8, 5 mg

A metabolite of JWH 122 that is characterized by monohydroxylation of the N-alkyl chain

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5,306

Medchemexpress LLC RR-11a analog | 685543-66-2 | 99.1% | 491.49 | 1 ML

RR-11a analog is a potent and irreversible inhibitor of *Schistosoma mansoni* legumain, with an IC50 of 31 nM. It is an aza-Asn derivative and an aza-peptide Michael acceptor. For research use only.

Potent and irreversible inhibitor of *Schistosoma mansoni* legumain
Aza-Asn derivative and aza-peptide Michael acceptor
Molecular weight: 491.49
Formula: C22H29N5O8
Appearance: Solid
Color: White to off-white
Solubility in DMSO: 125 mg/mL (254.33 mM; requires ultrasonic)
Solubility in H2O: 2.5 mg/mL (5.09 mM; requires ultrasonic and warming to 60°C)

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5,307

Medchemexpress LLC 9-[4-[(2-bromophenyl)methoxy]phenyl]-3,4,5,6,7,9-hexahydro-3,3,6,6-tetramethyl-1H-xanthene-1,8-dione | 1776115-10-6 | 99.1% | 10MM 1ML

9-[4-[(2-bromophenyl)methoxy]phenyl]-3,4,5,6,7,9-hexahydro-3,3,6,6-tetramethyl-1H-xanthene-1,8-dione | 1776115-10-6 | 99.1% | 10MM 1ML

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5,308

Avanti Polar Lipids MMG-1 5MG

MMG-1 5MG1:1 mixture of (2’R,2R,3S) and (2’R,2S,3R)-dihydroxypropyl 3-hydroxy-2-tetradecyloctadecanoate

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5,309

Cayman Chemical FGTI-2734, Purity: ≥95%, CAS: 1247018-19-4, 5 mg

A dual inhibitor of FTase and GGTase I (IC50s = 250 and 520 nM, respectively); inhibits prenylation of H-Ras and Rap1A (IC50s = 88.7 and 2,700 nM, respectively) in oncogenic H-Ras-transformed NIH3T3 cells; inhibits membrane localization of K-Ras in MIA PaCa-2 and H460 cancer cells at 10 and 30 µM; reduces tumor growth, increases intratumoral expression of p53, induces intratumoral apoptosis, and decreases intratumoral HDJ2 farnesylation and Rap1A geranylgeranylation in PDX mouse models of mutant KRAS-expressing pancreatic cancer at 50 and 100 mg/kg per day

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5,310

Medchemexpress LLC 1-Aminocyclopropane-1-carboxylic acid | 22059-21-8 | 95.6% | 101.10 | 50 MG

1-Aminocyclopropane-1-carboxylic acid | 22059-21-8 | 95.6% | 101.10 | 50 MG

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Bioactive Small Molecules

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Medchemexpress LLC Umibecestat | 1387560-01-1 | 99.8% | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Laropiprant | 571170-77-9 | 99.3% | 435.90 | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC RR-11a analog | 685543-66-2 | 99.1% | 491.49 | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 9-[4-[(2-bromophenyl)methoxy]phenyl]-3,4,5,6,7,9-hexahydro-3,3,6,6-tetramethyl-1H-xanthene-1,8-dione | 1776115-10-6 | 99.1% | 10MM 1ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Avanti Polar Lipids MMG-1 5MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 1-Aminocyclopropane-1-carboxylic acid | 22059-21-8 | 95.6% | 101.10 | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More